How to run safe mode in windows 10 Press Windows logo key Windows logo key + I on your keyboard to open Settings. If that doesn't work, select the Start button in the lower-left corner of your screen, then selectSettings. Select Update & security > Recovery. Under Advanced startup, select Restart now. After your PC restarts to the Choose an option screen, select Troubleshoot > Advanced options > Startup Settings > Restart. After your PC restarts, you'll see a list of options. Select 4 or F4 to start your PC in Safe Mode. Or if you'll need to use the Internet, select 5 or F5 for Safe Mode with Networking.